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Keep an eye on Closely (one)pentobarbital will lower the level or influence of benzhydrocodone/acetaminophen by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Caution when discontinuing CYP3A4 inducers which are coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone may perhaps enhance and may end up in probably fatal respiratory despair.
pentobarbital will minimize the level or effect of pimavanserin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Keep away from coadministration if possible. Watch for lowered pimavanserin efficacy. An increase in pimavanserin dosage can be essential.
pentobarbital will lower the extent or outcome of eletriptan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Continuously keep an eye on vital indications all through sedation and recovery period of time if coadministered. Diligently titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.
lasmiditan, pentobarbital. Either raises outcomes of the opposite by sedation. Use Warning/Monitor. Coadministration of lasmiditan along with other CNS depressant medicine, together with alcohol have not been evaluated in medical experiments. Lasmiditan might induce sedation, along with other cognitive and/or neuropsychiatric adverse reactions.
pentobarbital will minimize the level or effect of colchicine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Reserve concomitant prescribing of those medications in sufferers for whom other treatment solutions are inadequate. Restrict dosages and durations to your bare minimum required. Monitor closely for signs of respiratory melancholy and sedation.
pentobarbital will lessen the extent or impact of sildenafil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Powerful CYP3A4 inducers are predicted to cause considerable decreases in sildenafil plasma concentrations
pentobarbital will reduce the level or result of sufentanil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Mysterious.
pentobarbital will reduce the extent or impact more info of vincristine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unknown.
pentobarbital will decrease the extent or impact of netupitant/palonosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Netupitant is principally metabolized by CYP3A4; keep away from use in sufferers who are chronically applying a robust CYP3A4 inducer
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pentobarbital will lower the level or influence of nicardipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.